Skin Clinic

PDRN (Polydeoxyribonucleotide)

PDRN isn’t all that new. In a study in 2001 conducted in University of Siena, Italy, doctors found that skin graft patients who also received PDRN had significantly faster wound healing than those receiving placebo. PDRN was thus first approved for clinical use in Italy as a tissue repair stimulating agent.

PDRN exists in small amount in newly formed tissues. It standardizes the DNA structure into the right size, replacing the damaged and aged skin with young and healthy skin. As a deoxyribonucleotide linear polymer. PDRN selectively acts on the A2 purinergic receptor to help cell growth and neogenesis. It has been used for clinical treatment of orthopaedic conditions such as plantar fasciitis, other forms of chronic tendinosis and certain skin ulcers, with improved wound healing, relief of skin oedema and reduction of pain. In 2008, it was approved for use in tissue repair and treatment of wound in skin graft by Korean FDA.


PDRN enhances fibroblasts which boosts skin collagen

What is PDRN?

Polydeoxyribonucleotide (PDRN) contains deoxyribonucleotide polymers where 50 to 2000 base pairs are combined in a chain. It’s main claim to fame amongst aesthetic circles is its remarkable ability to aid regeneration of skin and tissue. In vitro, PDRN was shown to enhance the growth rate of human fibroblasts in primary cultures at therapeutic concentrations (20-100 µg/ml).

In initial studies, it was also one of the key ingredients used for clinical treatment of diabetic foot ulcers. This compound has since been used as a tissue repair-stimulating agent several dermatological conditions, such as ulcers and burns.

What is PDRN used for now?

As PDRN evolved, new uses were found for this exceptional skin healing agent. Conditions that required an activation of wound-healing processes, including depressed scars in patients suffering from acne also benefitted from the use of PDRN.

Since it helps the skin regeneration, it is ideal after certain laser treatments such as a Fraxel Light or SmartX Lite laser treatment. More innovative uses involved its use in anti-ageing and skin rejuvenation therapies.

Recent studies published in the 2016 International Journal of Molecular Sciences, Korean doctors also found that patients receiving intradermal PDRN showed improvements in their pigmentation and overall complexion whitening.

How can it help my skin?

PDRN is a vital ingredient that is not found in normal skincare. Incorporating this essential molecule into your skin will kickstartyour skin’s physiologic regeneration processes. This will reverse some of the age-related changes that has taken place in your skin as well as optimize your skin health to better withstand future assaults, so that you have the best defense against accelerated ageing caused by environment and lifestyle factors.

PDRN is most suitable for people with:

  • Poor healing – acne scars, marks
  • Skin discolouration – pigmentation, age spots
  • Age-related changes – dull, dry, rough skin, wrinkles and lines

How is this treatment administered?

In studies, PDRN is shown to be ideally administered in the following ways:

PDRN Perfection: topically using sonophoresis (ultrasound) after a Fraxel Light or SmartX Lite laser treatment. After these specific fractionated lasers, micro-channels are created in the skin which allow enhanced penetration of PDRN into the dermis. The application of sonophoresis aids in the penetration of the ingredient.

What kind of skin benefits will I see?

Patients will usually notice that their skin feels more supple, look more hydrated and have less wrinkles and fine lines from the first session, which improves over the next few sessions. A series of 4-6 sessions every 2 weeks is recommended to saturate the skin with the optimal dose of PDRN (Polydeoxyribonucleotide) to give you the most impact for your anti-ageing needs.

What are the side effects?

There are little to no side effects seen with this treatment so far as this is a superficial treatment. There is little to no downtime experienced by the patients undergoing this treatment as well, and all patients can wear makeup and return to normal activities after.

What can I combine this treatment with?

PDRN is a versatile adjunct to many aesthetic therapies but has particular advantages when used with specific laser treatments. PDRN is a versatile adjunct to many aesthetic therapies but has particular advantages when used with specific laser treatments. PDRN Perfection works in synergy with Lustrous Skin program and Dazzling Skin program, allowing favourable topical penetration of the ingredients post laser.

This treatment works nicely both on its own and when combined with any collagen-stimulating treatments such as Dream Sculpture or Trinity Facelift Program.

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